Shape optimization

Project summary

Nature and science have taught us that shape is an incredibly powerful means of interacting with biological systems. Complex shapes like pollen grains, viruses, and protein folds all exploit shape to achieve complex biological functions. If we can design particles to deliver drugs and therapies with the same efficiency, completely new therapies can be developed. We are in the enviable position of being able to create almost any shape particle we want, but we don’t know what works best!

Project objectives

  • Use a newly-developed liquid droplet system to systematically vary shape of microparticles for use as biomimics
  • Test the function of the shapes using biological systems like bacterials cultures
  • Adapt biological feedback to improve and evolve shapes into increasingly effective treatments